Paraskeletal Plasmacytoma Manifesting as a Chest Wall Mass - An Uncommon Presentation of Plasma Cell Disorder

Plasma cell tumors are characterised by the uncontrolled growth of differentiated B-lymphocytes, which produce monoclonal immunoglobulins. Involvement of the bone marrow or systemic symptoms can be observed. Plasma cell neoplasms that manifest as mass lesions can include extramedullary plasmacytoma or paraskeletal plasmacytoma. Solitary extramedullary plasmacytomas are rare tumors consisting of plasma cells located in soft tissues, appearing as isolated masses that do not involve bone structures. The term, paraskeletal plasmacytoma is used if they impact the skeletal system. We report a case of a middle aged Indian male who presented with a chest wall swelling and underwent an incisional biopsy before the diagnosis of paraskeletal plasmacytoma, which was confirmed through pathology but exhibited only minor systemic symptoms. This case report adds another rare example of multiple myeloma manifestation as a chest wall tumour to the medical community’s literature and ascertain the need of proper diagnosis distinguishing paraskeletal plasmacytomas from extramedullary disease to avoid unnecessary surgeries/tests/treatments.