ISSN (Online): 1694-4674
Annals of Medicine and Medical Sciences Annals of Medicine and Medical Sciences
Submit Manuscript
  1. Home
  2. Volume 04 (2025), Version 8
  3. Effectiveness and Safety of Co-Amoxiclav in Dental Infections: A Multi…
Original Article Open Access

Effectiveness and Safety of Co-Amoxiclav in Dental Infections: A Multicenter, Real-World Study

, , , , ,
Annals of Medicine and Medical Sciences Volume 04 (2025), Version 8 July 18, 2025 pp. 670 - 677
376 412
Download PDF
PDF XML
Abstract

Objective: To assess the clinical effectiveness and safety of Co-Amoxiclav in the real-world treatment of dental infections. Design: Multicenter, retrospective, real world evidence study. Subjects: 4,436 adults diagnosed with dental infections Methods: This study included patients aged ≥ 18 years with a confirmed diagnosis of dental infections, who were treated with co-amoxiclav and had complete treatment documentation, including both baseline and follow-up visits. Data were extracted from medical records. The primary endpoints were the therapeutic efficacy and safety of co-amoxiclav. Statistical analysis included descriptive statistics and the paired t-test. Results: The mean age of participants was 40.23 ± 12.20 years, while the most common diagnoses was undifferentiated dental infections (52%). Co-amoxiclav 625 mg twice daily for 5–7 days was the most common regimen (40.98%), with 95.55% reporting complete symptom resolution at 7 ± 2 days. Significant reductions were observed in C-reactive protein, white blood cell count, and Visual Analog Scale pain scores (p < 0.0001), with minimal treatment-related adverse events (0.16%). Conclusion: Co-amoxiclav exhibited robust clinical effectiveness and a favourable safety profile in treating dental infections, with most patients achieving complete symptom resolution and a low incidence of adverse events.

References
  1. Słotwińska-Pawlaczyk A, Orzechowska-Wylęgała B, Latusek K, Roszkowska AM. Analysis of the clinical status and treatment of facial cellulitis of odontogenic origin in pediatric patients. International Journal of Environmental Research and Public Health [Internet]. 2023 Mar 10;20(6):4874. Available from: https://doi.org/10.3390/ijerph20064874
  2. Prakash SK. Dental abscess: A microbiological review Shweta 1. 2013; 10:585–91.
  3. Laudenbach JM, Kumar SS. Common dental and periodontal diseases. Dermatol Clin [Internet]. 2020;38(4):413–20. Available from: http://dx.doi.org/10.1016/j.det.2020.05.002
  4. Babaiwa UF, Osia EA, Ugbodaga P, Akerele JO. Epidemiology of odontogenic infections in a secondary healthcare centre in Southern Nigeria. J Pharm Biore Sources [Internet]. 2017;14(1):38. Available from: http://dx.doi.org/10.4314/jpb.v14i1.5
  5. Santacroce L, Passarelli PC, Azzolino D, Bottalico L, Charitos IA, Cazzolla AP, et al. Oral microbiota in human health and disease: A perspective. Exp Biol Med (Maywood) [Internet]. 2023;248(15):1288–301. Available from: http://dx.doi.org/10.1177/15353702231187645
  6. Meinen A, Reuss A, Willrich N, Feig M, Noll I, Eckmanns T, et al. Antimicrobial resistance and the spectrum of pathogens in dental and oral-maxillofacial infections in hospitals and dental practices in Germany. Front Microbiol [Internet]. 2021; 12:676108. Available from: http://dx.doi.org/10.3389/fmicb.2021.676108
  7. Osuh ME, Oke GA, Lilford RJ, Osuh JI, Harris B, Owoaje E, et al. Systematic review of oral health in slums and non-slum urban settings of Low and Middle-Income Countries (LMICs): Disease prevalence, determinants, perception, and practices. PLoS One [Internet]. 2024;19(11):e0309319. Available from: http://dx.doi.org/10.1371/journal.pone.0309319
  8. Pandey P, Nandkeoliar T, Tikku AP, Singh D, Singh MK. Prevalence of dental caries in the Indian population: A systematic review and meta-analysis: A systematic review and meta-analysis. J Int Soc Prev Community Dent [Internet]. 2021;11(3):256–65. Available from: http://dx.doi.org/10.4103/jispcd.JISPCD_42_21
  9. Osuh ME, Oke GA, Lilford RJ, Owoaje E, Harris B, Taiwo OJ, et al. Prevalence and determinants of oral health conditions and treatment needs among slum and non-slum urban residents: Evidence from Nigeria. PLOS Glob Public Health [Internet]. 2022;2(4):e0000297. Available from: http://dx.doi.org/10.1371/journal.pgph.0000297
  10. Jain N, Dutt U, Radenkov I, Jain S. WHO’s global oral health status report 2022: Actions, discussion and implementation. Oral Dis [Internet]. 2024;30(2):73–9. Available from: http://dx.doi.org/10.1111/odi.14516
  11. Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin Microbiol Rev [Internet]. 2000;13(4):547–58. Available from: http://dx.doi.org/10.1128/cmr.13.4.547
  12. Thompson W, Teoh L, Hubbard CC, Marra F, Patrick DM, Mamun A, et al. Patterns of dental antibiotic prescribing in 2017: Australia, England, United States, and British Columbia (Canada). Infect Control Hosp Epidemiol [Internet]. 2022;43(2):191–8. Available from: http://dx.doi.org/10.1017/ice.2021.87
  13. Contaldo M, Ambrosio F, Ferraro GA, Stasio D, Palo D, Serpico MP, et al. Antibiotics in Dentistry: A Narrative Review of the Evidence beyond the Myth.20(11):6025. 2023;20.
  14. Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T. 2015;40(4):277–83.
  15. Ahmadi H, Ebrahimi A, Ahmadi F. Antibiotic therapy in dentistry. Int J Dent [Internet]. 2021; 2021:6667624. Available from: http://dx.doi.org/10.1155/2021/6667624
  16. Bush K, Bradford PA. Β-lactams and β-lactamase inhibitors: An overview. Cold Spring Harb Perspect Med [Internet]. 2016;6(8). Available from: http://dx.doi.org/10.1101/cshperspect.a025247
  17. Tancawan AL, Pato MN, Abidin KZ, Asari ASM, Thong TX, Kochhar P, et al. Amoxicillin/clavulanic acid for the treatment of odontogenic infections: A randomised study comparing efficacy and tolerability versus clindamycin. Int J Dent [Internet]. 2015;2015:472470. Available from: http://dx.doi.org/10.1155/2015/472470
  18. Adriaenssen CF. Comparison of the efficacy, safety and tolerability of azithromycin and co-amoxiclav in the treatment of acute periapical abscesses. J Int Med Res [Internet]. 1998;26(5):257–65. Available from: http://dx.doi.org/10.1177/030006059802600506
  19. Sulejmanagić N, Sulejmanagić H, Ljutović Z, Salihagić D, Sijercić M. Combined application of amoxicillin and clavulanic acid after oral surgical interventions. Bosn J Basic Med Sci [Internet]. 2005;5(1):61–8. Available from: http://dx.doi.org/10.17305/bjbms.2005.3337
  20. Halling F, Neff A, Heymann P, Ziebart T. Trends in antibiotic prescribing by dental practitioners in Germany. J Craniomaxillofac Surg [Internet]. 2017;45(11):1854–9. Available from: http://dx.doi.org/10.1016/j.jcms.2017.08.010
  21. Choudhury J, Makkar A, Sharma V, Karamath SP, Parmar V, Kumar J P, et al. A real-world perspective of co-amoxiclav prescription pattern with probiotics for pediatric patients with respiratory tract infections: Results of quantitative and qualitative approach in Indian outpatient settings. Cureus [Internet]. 2023;15(3): e36269. Available from: http://dx.doi.org/10.7759/cureus.36269
  22. Sobottka I, Cachovan G, Stürenburg E, Ahlers MO, Laufs R, Platzer U, et al. In vitro activity of moxifloxacin against bacteria isolated from odontogenic abscesses. Antimicrob Agents Chemother [Internet]. 2002;46(12):4019–21. Available from: http://dx.doi.org/10.1128/AAC.46.12.4019-4021.2002
  23. Robertson D, Smith AJ. The microbiology of the acute dental abscess. J Med Microbiol [Internet]. 2009;58(Pt 2):155–62. Available from: http://dx.doi.org/10.1099/jmm.0.003517-0
  24. AlShammari A, AlSaleh S, AlKandari A, AlSaqabi S, AlJalahmah D, AlSulimmani W, et al. The association between dental caries and serum crp in the us adult population: evidence from NHANES 2015-2018. BMC Public Health [Internet]. 2024;24(1):2210. Available from: http://dx.doi.org/10.1186/s12889-024-19681-6
  25. Lim MY, Kim J-H, Nam Y-D. Oral microbiome correlates with selected clinical biomarkers in individuals with no significant systemic disease. Front Cell Infect Microbiol [Internet]. 2023; 13:1114014. Available from: http://dx.doi.org/10.3389/fcimb.2023.1114014
  26. Huang H, Li L, Wu M, Liu Z, Zhao Y, Peng J, et al. Antibiotics and antibiotic-associated diarrhea: a real-world disproportionality study of the FDA adverse event reporting system from 2004 to 2022. BMC Pharmacol Toxicol [Internet]. 2023;24(1):73. Available from: http://dx.doi.org/10.1186/s40360-023-00710
Author Resources