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Clinical Profile and Outcomes of COVID-19 in Elderly Patients of a Tertiary Care Centre

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Annals of Medicine and Medical Sciences Volume 04 (2025), Version 8 July 20, 2025 pp. 709 - 714
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Abstract

Objective: To assess the clinical profile, comorbidities, complications, and outcomes of elderly COVID-19 patients admitted to a tertiary care hospital in India. Design: Descriptive cross-sectional observational study. Subjects/Patients: 171 elderly patients (≥60 years) with RT-PCR-confirmed COVID-19. Methods: Patient records were reviewed for demographic details, symptoms, comorbidities, vitals, oxygen requirements, lab findings, complications, and outcomes. Statistical analysis included Chi-square and t-tests (p<0.05 considered significant). Results: Mean age was 71.01 ± 6.66 years; 49.7% were male. Common comorbidities included diabetes (45.6%) and hypertension (32.7%). Fever (79.5%) and cough (50.9%) were the most frequent symptoms. Hypoxia was present in 84.8%, and 25.1% required mechanical ventilation. Pneumonia (78.3%), ARDS (25.1%), and AKI (16.3%) were the main complications. Mortality was 25.1%, highest in those >80 years (58.8%). Hypertension, diabetes, ischemic heart disease, ≥3 comorbidities, and elevated WBC, CRP, LDH, IL-6, ferritin, and HbA1c were significantly associated with mortality. Conclusion: Elderly COVID-19 patients with comorbidities and elevated inflammatory or metabolic markers face a significantly higher risk of death. Early detection and aggressive management are essential to reduce mortality.

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